Upstream Biotechnology, Inc
Harnessing Plant Immunity
to Feed the Future
As climates change, plants need stronger defenses to fight devastating
diseases and
abiotic stresses. Upstream creates natural RNA-based solutions
to increase plant
resilience for sustainable food production.
Our Technology
Creating solutions for sustainable solutions for food production. Our patented genetic platform modulate plant immunity for broad spectrum resistance with no yield drag
Upstream Biotechnology, Inc is delivering next generation of traits to address
global targets for food security in the face of a changing climate.

Our SwitchBlade Technology
We give crops their own on-demand stress response. Our RNA Switches quietly monitor for stress and then flip the plant’s natural defenses on at the right time and in the right tissues, delivering broad protection with no yield drag. Fewer sprays, more reliable yield, climate-smart.
Product Pipeline
Upstream Biotechnology, Inc is delivering next generation of traits to address global targets for food security in the face of a changing climate.
SwitchBlade Pipeline




We are interested in partnering with Seed Companies at all stages in these target crops, or
others of interest, for development of resistance traits.

Our Team Members
We are a dedicated team of plant technology pioneers, creating powerful seed-based solutions to improve grower profitability and build resilience in the value chain.

George Greene
CEO | Co-Founder

Xinnian Dong
Advisor | Co-Founder

Tim Kroenke
VP Business Development

John Salmeron
Crop Portfolio Lead

Jun Cao
Transformation Lead

Tianyuan Chen
Senior Scientist
Latest News Updates
Check out some of news and articles below

Researchers Discover How Plants Reprogram Their Cells To Fight Invaders
Researchers uncover how plants reprogram cells to strengthen immunity and defend against harmful pathogens.

We won a spot in the AgLaunch365
2024 cohort in November of 2023
Upstream Biotechnology earned a spot in the AgLaunch365 2024 cohort, announced in November 2023.

We began small plot field trails for
the soy resistance trait in June 2024
Small plot field trials for the soy resistance trait were initiated by Upstream in June 2024.

Researchers Discover How Plants Reprogram Their Cells To Fight Invaders
Researchers uncover how plants reprogram cells to strengthen immunity and defend against harmful pathogens.

We won a spot in the AgLaunch365
2024 cohort in November of 2023
Upstream Biotechnology earned a spot in the AgLaunch365 2024 cohort, announced in November 2023.

We began small plot field trails for
the soy resistance trait in June 2024
Small plot field trials for the soy resistance trait were initiated by Upstream in June 2024.
Latest News Updates
Check out some of news and articles below

JUN
24

Researchers Discover How Plants Reprogram Their Cells To Fight Invaders
Researchers uncover how plants reprogram cells to strengthen immunity and defend against harmful pathogens.


We won a spot in the AgLaunch365
2024 cohort in November of 2023
Upstream Biotechnology earned a spot in the AgLaunch365 2024 cohort, announced in November 2023.

We began small plot field trails for
the soy resistance trait in June 2024
Small plot field trials for the soy resistance trait were initiated by Upstream in June 2024.

Contact Us
We would like to talk to companies interested in using Upstream's proprietary gene expression platform for optimizing trait performance. We also collaborate with companies interested in evaluating our seed products in greenhouse or field tests.
