UPSTREAM BIOTECH

Our Technology

Trait technology is a major reason for the increases in crop yields over the past two decades. Adoption of first-generation traits such as insect resistance and herbicide tolerance has been swift, with over 90% of corn, soybeans and cotton carrying these proven value drivers. Yet the pace of discovery for new trait modes-of-action has slowed considerably. Upstream Biotechnology is positioned to deliver the next generation of traits to enable growers with ever higher yields.

Engineering traits for crop resilience is critical for improving yields in the face of a changing environment. Upstream Biotechnology has unlocked an understanding of how the regulation of plant genes can be most optimally tuned to offer yield benefits. Many trait genes have been shown to perform well but show high variability in performance across environments. Upstream’s proprietary technology platform reduces turbulence in trait performance to support plant health throughout development resulting in top yields.

Technological Challenges

Uncontrolled trait expression leads to unintended off-target effects and sensitivities that limit plant performance. Upstreams platform smoothes out trait expression for robust and reliable performance. 

Corn

Corn production is threatened by a variety of fungal diseases each harvest. Current disease management relies on the heavy use of broad-spectrum fungicides. Pathogens have begun evolving resistance to these fungicides, reducing their efficacy. Switchblade is being developed in corn to deliver a durable broad-spectrum resistance alternative for growers. 

Citrus

Huanglongbing (HLB) or Citrus Greening is the most devastating citrus diseases worldwide. Infection results in stunting of tree growth, loss of fruit quality and ultimately death. There are no current fungicide or genetic resistance traits to effectively control the spread of HLB. This bacterial disease has crippled Florida citrus production and is currently threatening California production. Switchblade is being developed in citrus to provide viable genetic solution to this crisis. 

Tomatoes

Tomatoes are grown throughout the world as an essential staple of many cuisines. SwitchBlade is being developed in this crop to provided broad-spectrum resistance to the over 200 different diseases tomato is vulnerable to, including a variety of fungi, bacteria, nematodes, and virus. 

Soy

Soy rust is a devastating disease resulting in over a billion dollars in lost production each year. On the left, you see plants without effective resistance. On the right, the effective resistance of Switchblade soy plant. 

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SwitchBlade

SwitchBlade Performance In Rice

Rice production is threatened by a wide variety of pathogens each year. The broad-spectrum resistance of SwitchBlade has demonstrated resistance to fungal blast (below), bacterial leaf streak, and bacterial blight – these are among the most devastating diseases in rice!

SwitchBlade Rice is resistant to major diseases. Left is the control plant and the right is SwitchBlade.