UPSTREAM BIOTECH

About Us

From its origins in foundational technology discovered at Duke University, Upstream Biotechnology has built established a new platform for the development of leading seed products, based on a proprietary strategy for deployment of value-added traits.

Our Mission

With the world population set to top 10 billion by 2050, agriculture faces the need to ratchet its outputs ever higher. In recent years, pandemics, wars, and extreme weather events have added new risks to supply chains that were already fragile. Farmers and the food value chain urgently need new paths to crop yield enhancement that are consistent, resilient, and that fit into existing cropping systems. 

  Upstream Biotechnology is dedicated to the discovery and development of the next generation of seed traits to help growers meet the demands of this new agricultural landscape.

Founders

Upstream Biotechnology’s founders are deeply committed to translating fundamental knowledge about how plants respond to their environment into high-performing crop varieties benefiting growers and the food value chain.  

George Greene

Founder

Xinnian Dong

Founder

Strategic Advisors

Corn

Corn production is threatened by a variety of fungal diseases each harvest. Current disease management relies on the heavy use of broad-spectrum fungicides. Pathogens have begun evolving resistance to these fungicides, reducing their efficacy. Switchblade is being developed in corn to deliver a durable broad-spectrum resistance alternative for growers. 

Citrus

Huanglongbing (HLB) or Citrus Greening is the most devastating citrus diseases worldwide. Infection results in stunting of tree growth, loss of fruit quality and ultimately death. There are no current fungicide or genetic resistance traits to effectively control the spread of HLB. This bacterial disease has crippled Florida citrus production and is currently threatening California production. Switchblade is being developed in citrus to provide viable genetic solution to this crisis. 

Tomatoes

Tomatoes are grown throughout the world as an essential staple of many cuisines. SwitchBlade is being developed in this crop to provided broad-spectrum resistance to the over 200 different diseases tomato is vulnerable to, including a variety of fungi, bacteria, nematodes, and virus. 

Soy

Soy rust is a devastating disease resulting in over a billion dollars in lost production each year. On the left, you see plants without effective resistance. On the right, the effective resistance of Switchblade soy plant. 

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SwitchBlade

SwitchBlade Performance In Rice

Rice production is threatened by a wide variety of pathogens each year. The broad-spectrum resistance of SwitchBlade has demonstrated resistance to fungal blast (below), bacterial leaf streak, and bacterial blight – these are among the most devastating diseases in rice!

SwitchBlade Rice is resistant to major diseases. Left is the control plant and the right is SwitchBlade.