Harnessing Plant Immunity to Feed the Future

Upstream Biotechnology, Inc

As climates change, plants need stronger defenses to fight devastating diseases and abiotic stresses. Upstream creates natural RNA-based solutions to increase plant resilience for sustainable food production.

Our Technology

We give crops their own on-demand stress response. Our RNA Switches quietly monitor for stress and then flip the plant’s natural defenses on at the right time and in the right tissues, delivering broad protection with no yield drag. Fewer sprays, more reliable yield, climate-smart.

Product Pipeline

Upstream Biotechnology, lnc is delivering next generation of traits to address global targets for food security in the face of a changing climate.


SwitchBlade Pipeline

Proof Of Concept

Field Validation

Establishing Partnership

Development Commercialization

We are interested in partnering with Seed Companies at all stages in these target crops, orothers of inter, for development of resistance traits.

We are a dedicated team of plant technology pioneers, creating powerful seed-based solutions to improve grower profitability and build resilience in the value chain.

Our Team Members

George Greene

CEO & Co Founder

Xinnian Dong

Co-Founder

Jun Cao

Transformation Lead

Tim Kroenke

VP Business Development

Tianyuan Chen

Senior Scientist

John Salmeron

Crop Portfolio Lead

Latest News Updates

Check out some of news and articles below

Researchers Discover How Plants Reprogram Their Cells To Fight Invaders

Researchers uncover how plants reprogram cells to strengthen immunity and defend against harmful pathogens

We won a spot in the AgLaunch365
2024 cohort in November of 2023

Upstream Biotechnology earned a spot in the AgLaunch365 2024 cohort, announced in November 2023.

We began small plot field trails for
the soy resistance trait in June 2024

Small plot field trials for the soy resistance trait were initiated by Upstream in June 2024.

Contact Us

We would like to talk to companies interested in using Upstream's proprietary gene expression platform for optimizing trait performance. We also collaborate with companies interested in evaluating our seed products in greenhouse or field tests.